13,thirty Also, CCL2 has long been noted to reinforce osteoclastogenesis by inducing the expression of receptor activator of NF-?B (RANK) by osteoclast progenitors.31 RANK ligand (RANKL) further promotes the differentiation of osteoclast progenitors into practical osteoclasts, which could aggravate DP by leading to alveolar bone resorption.32 These